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|Dimensions||5 x 3 x 8 cm|
While agmatine is known for its efficacy as a vasodilator, beneficial for athletes in improving oxygenation of muscle tissue and supporting muscle recovery, what is unique about agmatine is its action in the brain. Agmatine is a product of the metabolism of the amino acid arginine, and appears to be stored in brain cells and released when those cells are activated. This is partially due to agmatine’s ability to cross the blood-brain barrier, which could help give athletes a mental edge provided by mood support, as well as analgesic-like, exercise-related pain management.
Agmatine supports the metabolism of glucose in muscle by enhancing and improving the body’s insulin response.(1) Insulin stimulates nutrient transporters to shuttle glucose and amino acids into the muscle cell, while preventing these nutrients from becoming stored in the body. This has long been thought to be one of the biggest keys to building a leaner, harder, and more muscular body. Additionally, agmatine is thought to stimulate the production of growth hormone(GH) and luteinizing hormone(LH) which can also have positive effects on overall body composition.(2) GH stimulates protein synthesis and mobilizes fat to be used as energy over carbs, while LH stimulates the release of testosterone which in turn increases base metabolic rate, decreases body fat; and maintains muscle volume, tone, and strength.
Agmatine has long been established as an agent in nitric oxide (NO) production, a molecule that stimulates vasodilation (the widening of blood vessels), and increased blood flow.(3) Proper blood flow is critical for athletes as there is a need for an increased volume of oxygenated blood to travel to stressed muscles. It also ensures that enough water, carbs, and amino acids are reaching the muscles to allow for protein synthesis; the building of muscles. NO has also been reputed to reduce the oxygen cost of muscle contractions, effectively improving “fuel mileage” during endurance exercise.
Extensive animal research has shown that agmatine has a role in modulating pain response and mood level in the brain. In these models, agmatine has effectively blocked stimuli from inflammation, mechanical pain, and nerve pain from being detected by sensory neurons, acting as an analgesic.(4) Agmatine’s ability to help mitigate exercise-related pain in animals could prove to have a major impact on both competitive athletes and weekend warriors who may be able to train through minor aches and pains at higher levels than they would otherwise be able to. Agmatine has also been shown to elicit antidepressant responses in rodents. When placed in a stressful situation with no escape, immobility in the rodent (when they stop trying to escape) is considered to represent a depressive state. In all such studies agmatine has been shown to act as anti-depressant, increasing the time the rodent spends in escape attempts.(4) This potential motivational effect could have huge implications for athletes, allowing them to power through rigorous workouts, stick to nutrition plans, and maintain a mental edge.
(1)Nissim, I., Horyn, O., Daikhin, Y., Chen, P., Li, C., Wehrli, S. L., et al. (2014). The molecular and metabolic influence of long term agmatine consumption. The Journal of Biological Chemistry, 289(14), 9710-9729. doi:10.1074/jbc.M113.544726 [doi]
(2) Kalra, S. P., Pearson, E., Sahu, A., & Kalra, P. S. (1995). Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neuroscience Letters, 194(3), 165-168.
(3) Joshi, M. S., Ferguson, T. B., Johnson, F. K., Johnson, R. A., Parthasarathy, S., & Lancaster, J. R. (2007). Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 104(24), 9982–9987.
(4)Uzbay, T. I. (2012). The pharmacological importance of agmatine in the brain. Neuroscience & Biobehavioral Reviews, 36(1), 502-519.
- Color (in powder form)
- White to Off-White
- Product Flavor Profile (mixed with 8-10 oz. water)
- Neutral taste
- Suggested Flavor Pairings
- Any: Works well with all of our 12 flavor offerings. Choose your favorite!
- Alternative Uses: Add to…
- Cold Beverages (juice, milk, iced tea, etc.)
- Sports Drinks