L-Citrulline - ThinkitDrinkit
  • L-Citrulline - ThinkitDrinkit



L-Citrulline is used as a sports performance and cardiovascular health supplement. L-Citrulline supplementation has been shown to reduce fatigue and improve endurance for both aerobic and anaerobic prolonged exercise. L-Citrulline has additional benefits; it promotes muscle building, cellular waste elimination and proper immune function, as well as vascular health and supporting normal erectile function. Since L-Citrulline is not a component of proteins unlike most other amino acids, dietary proteins cannot be a direct source of L-Citrulline to the body.


Servings: 15   Price Per Serving: $0.23



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Product Description

*This statement has not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.

Additional Information

Weight 47 g
Dimensions 5 x 3 x 8 cm

More Information

L-Citrulline is from Kyowa’s extensive line of ultra-pure amino acids, backed by their commitment to the highest standards in: Purity, Quality Assurance, Science, Reliability & Excellence.

L-Citrulline is a naturally occurring precursor to the amino acid L-Arginine, which produces nitric oxide (NO), a molecule that stimulates the widening of the blood vessels.  L-Citrulline is potentially a more effective supplement than L-Arginine itself, as it is not eliminated by the liver or used by enterocytes (cells that absorb nutrients in the intestines), before entering the bloodstream(1).  NO is important to athletes as it supports normal oxygen and blood circulation throughout the body.  Studies have even shown that L-Cirtulline improves blood flow to the extremities and raises body surface temperatures, great for fitness enthusiasts who enjoy a cold weather workout, or those who simply have poor circulation(2).

L-Citrulline is also involved in the urea cycle.  It is part of the metabolic process that converts ammonia, a toxin that accumulates in the muscles during exercise, into a waste product (urea) that is eliminated from the body.  Thus, L-Citrulline aides in releasing this toxin from the muscles, allowing them to resist fatigue(3).

Novel research has raised the potential for L-Citruline to play a role in healthy immune response, with application to sports recovery.  A 2009 study of professional cyclists demonstrated that supplementing with L-Citrulline before a cycling stage, increased the metabolic activity of neutrophils (the family of white blood cells responsible for immediate immune response) directly following the race(4).  Citrulline’s immune boost may benefit endurance athletes as it has been established that immune defenses drop after intense athletic events, increasing susceptibility to infection.   It has additional relevance to the inflammatory immune response.  A 2011 study in rats with sepsis (bacterial infection) observed that feeding L-Citrulline decreased the proinflammatory response without impairing anti-inflammatory proteins, on the whole reducing inflammation(5).  Consequently, L-Citrulline likely would have similar anti-inflammatory effects on muscles after exercise.

Finally, L-Cirtrulline offers benefits to those participating in high intensity or strength and power workouts by promoting anaerobic muscle metabolism.  A recent 2013 study supplemented a group of rats’ diets for one week with L-Citruline, and resulted in increased expression of myofibrillar proteins (the base units of muscles), and enzymes involved in glycolysis (the mechanism for anaerobic respiration)(6).  A human clinical study in 2008 indicated similar results, where L-Citrulline anaerobically stimulated muscle protein synthesis(7).


  1. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., et al. (2013). Citrulline: From metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479-484.
  2. Willoughby, D. L-Citrulline: It’s Role as a Nitric Oxide Donor, Circulation Enhancer, and Promoter of Cardiovascular Health and Muscle Protein Accretion. [PDF Document] Retrieved From International Society of Sports Nutrition Web site:
  3. Ortolani, E. L., & Marcondes, M. C. (1995). Treatment of ammonia intoxication in rats through the use of amino acids from the urea cycle. Veterinary and Human Toxicology, 37(3), 217-220.
  4. Sureda, A., Cordova, A., Ferrer, M. D., Tauler, P., Perez, G., Tur, J. A., et al. (2009). Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radical Research, 43(9), 828-835.
  5. Asgeirsson, T., Zhang, S., Nunoo, R., Mascarenas, C., Dujovny, N., Luchtefeld, M., et al. (2011). Citrulline: A potential immunomodulator in sepsis. Surgery, 150(4), 744-751.
  6. Faure, C., Morio, B., Chafey, P., Le Plenier, S., Noirez, P., Randrianarison-Huetz, V., et al. (2013). Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats. Proteomics, 13(14), 2191-2201.
  7. Jourdan, M., Nair, K. S., Ford, C., Shimke, J., Ali, B., Will, B., et al. (2008). Citrulline stimulates muscle protein synthesis at the post-absorptive state in healthy subjects fed a low-protein diet. Clinical Nutrition Supplements, 3, Supplement 1(0), 11-12


  • Color (in powder form)
    • White
  • Product Flavor Profile (mixed with 8-10 oz. water)
    • Neutral taste
  • Suggested Flavor Pairings
    • Any: Works well with all of our 12 flavor offerings. Choose your favorite!
  • Alternative Uses: Add to…
    • Cold Beverages (juice, milk, iced tea, etc.)
    • Hot Beverages (coffee, tea, etc.)
    • Sports Drinks
    • Smoothies
    • Yogurt


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